[Update] ‘Omics’ Sciences: Genomics, Proteomics, and Metabolomics | omics – Pickpeup

omics: คุณกำลังดูกระทู้

Pocket K No. 15: ‘Omics’ Sciences: Genomics, Proteomics, and Metabolomics

Genomics

Genomics is the new science that deals with the discovery and noting of all the sequences in the entire genome of a particular organism. The genome can be defined as the complete set of genes inside a cell. Genomics, is, therefore, the study of the genetic make-up of organisms.

Determining the genomic sequence, however, is only the beginning of genomics. Once this is done, the genomic sequence is used to study the function of the numerous genes (functional genomics), to compare the genes in one organism with those of another (comparative genomics), or to generate the 3-D structure of one or more proteins from each protein family, thus offering clues to their function (structural genomics).

In crop agriculture, the main purpose of the application of genomics is to gain a better understanding of the whole genome of plants. Agronomically important genes may be identified and targeted to produce more nutritious and safe food while at the same time preserving the environment.

Genomics is an entry point for looking at the other ‘omics’ sciences. The information in the genes of an organism, its genotype, is largely responsible for the final physical makeup of the organism, referred to as the “phenotype”. However, the environment also has some influence on the phenotype.

DNA in the genome is only one aspect of the complex mechanism that keeps an organism running – so decoding the DNA is one step towards understanding the process. However, by itself, it does not specify everything that happens within the organism.

The basic flow of genetic information in a cell is as follows. The DNA is transcribed or copied into a form known as “RNA”. The complete set of RNA (also known as its transcriptome) is subject to some editing (cutting and pasting) to become messenger-RNA, which carries information to the ribosome, the protein factory of the cell, which then translates the message into protein.

Figure 1. Genes, proteins, and molecular machines

Source: U.S. Department of Energy Genomes to Life Program, http://doegenomestolife.org

The International Rice Genome Sequencing Project

This ongoing genomic research in rice is a collaborative effort of several public and private laboratories worldwide. This project aims to completely sequence the entire rice genome (12 rice chromosomes) and subsequently apply the knowledge to improve rice production.
In 2002, the draft genome sequences of two agriculturally important subspecies of rice, indica and japonica, were published. Once completed, the rice genome sequence will serve as a model system for other cereal grasses and will assist in identifying important genes in maize, wheat, oats, sorghum, and millet.
For more, visit http://rgp.dna.affrc.go.jp/IRGSP

Proteomics

Proteins are responsible for an endless number of tasks within the cell. The complete set of proteins in a cell can be referred to as its proteome and the study of protein structure and function and what every protein in the cell is doing is known as proteomics. The proteome is highly dynamic and it changes from time to time in response to different environmental stimuli. The goal of proteomics is to understand how the structure and function of proteins allow them to do what they do, what they interact with, and how they contribute to life processes.

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An application of proteomics is known as protein “expression profiling” where proteins are identified at a certain time in an organism as a result of the expression to a stimulus. Proteomics can also be used to develop a protein-network map where interaction among proteins can be determined for a particular living system.

Proteomics can also be applied to map protein modification to determine the difference between a wild type and a genetically modified organism. It is also used to study protein-protein interactions involved in plant defense reactions.

For example, proteomics research at Iowa State University, USA includes:

  • an examination of changes of protein in the corn proteome during low temperatures which is a major problem for young corn seedlings;
  • analysis of the differences that occur in the genome expression in developing soybean stressed by high temperatures; and
  • identifying the proteins expressed in response to diseases like soybean cyst nematode.

 

Metabolomics

Metabolomics is one of the newest ‘omics’ sciences. The metabolome refers to the complete set of low molecular weight compounds in a sample. These compounds are the substrates and by-products of enzymatic reactions and have a direct effect on the phenotype of the cell. Thus, metabolomics aims at determining a sample’s profile of these compounds at a specified time under specific environmental conditions.

Genomics and proteomics have provided extensive information regarding the genotype but convey limited information about phenotype. Low molecular weight compounds are the closest link to phenotype.

Metabolomics can be used to determine differences between the levels of thousands of molecules between a healthy and diseased plant. The technology can also be used to determine the nutritional difference between traditional and genetically modified crops, and in identifying plant defense metabolites.

Figure 2. Example of a metabolic network model for E. coli

Source: U.S. Department of Energy Genomes to Life Program, http://doegenomestolife.org

 

Figure 2. Example of a metabolic network model for E. coli

Source: http://biotech.nature.com

 

Genomics provides an overview of the complete set of genetic instructions provided by the DNA, while transcriptomics looks into gene expression patterns. Proteomics studies dynamic protein products and their interactions, while metabolomics is also an intermediate step in understanding organism’s entire metabolism.

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Glossary

Chromosome: a grouping of coiled strands of DNA, containing many genes.

DNA (deoxyribonucleic acid): a molecule found in cells of organisms that encodes genetic information.

Gene: a biological unit that codes for distinct traits or characteristics.

Genome: the complete set of genes in a cell.

Genotype: the genetic constitution of an organism.

Metabolome: complete set of low molecular weight compounds in a cell at a given time.

Phenotype: the physical appearance/observable characteristics of an organism.

Proteome: complete set of proteins in a cell at a given time.

RNA (ribonucleic acid): a molecule, derived from DNA by transcription, that either carries information (messenger RNA), provides sub-cellular structure (ribosomal RNA), transports amino acids (transfer RNA), or facilitates the biochemical modification of itself or other RNA molecules.

References:

  1. Genomics and Its impact on Medicine and Society. A 2001 primer. http://www.ornl.gov/TechResources/Human_Genome/publicat/primer2001/1.html
  2. Primer on Molecular Genetics. http://www.ornl.gov/TechResources/Human_Genome/publicat/primer/primer.pdf
  3. Plant Sciences Institute Update. Iowa State University. October 2001. Volume 2 No.1.
  4. Genome Projects. http://www.tigr.org/tdb
  5. Meet the ‘omics’ 2003 Agbiotech Infosource. Saskatchewan Agricultural Biotechnology Information Centre, A service of Ag-West Biotech Inc.

*November 2006

Next Pocket K: Global Status of Commercialized Biotech/GM Crops


Omics Technology : Part 1


Systems biology is a holistic approach in biomedical research to understanding the larger picture at the level of :
organism,
tissue,
or cell
by putting its pieces together.
It’s a contrast to reductionist biology, which involves seeing things in isolation
Automated DNA sequencers enabled the sequencing of genomes; microarray and mass spectrometry analysis permit global transcriptional profiling and lead to largescale proteomic and metabolomics analysis.
These highthroughput data need to be interpreted by bioinformatics.

นอกจากการดูบทความนี้แล้ว คุณยังสามารถดูข้อมูลที่เป็นประโยชน์อื่นๆ อีกมากมายที่เราให้ไว้ที่นี่: ดูความรู้เพิ่มเติมที่นี่

Omics Technology : Part 1

Bringing all the omics together


Dr. Szilard Voros, CEO of Global Genomics Group (G3), shares how he and his team of researchers embarked on an ambitious journey to transform drug discovery using big data. With 48 participating clinical sites, three continents, nine countries, and nearly 8,000 patients, the study is the largest clinical trial to date that has used a multiomics approach to look at trends in disease states.
Subscribe to the Illumina video channel http://www.youtube.com/subscription_center?add_user=IlluminaInc

A global genomics leader, Illumina provides comprehensive nextgeneration sequencing solutions to the research, clinical, and applied markets. Illumina technology is responsible for generating more than 90% of the world’s sequencing data. Through collaborative innovation, Illumina is fueling groundbreaking advancements in oncology, reproductive health, genetic disease, microbiology, agriculture, forensic science, and beyond.

Data calculations on file. Illumina, Inc., 2015.

View customer spotlight videos
https://www.youtube.com/playlist?list=PLKRu7cmBQlajfheLzgbI4S7xBn7IDbt79

View Illumina webinars
https://www.youtube.com/playlist?list=PLKRu7cmBQlahpXlnrrXlQw9itVJ8yHwUZ

View Illumina product videos
https://www.youtube.com/playlist?list=PLKRu7cmBQlaj6YuZmkfxZcT9twqDgP2Xd

View Illumina support videos
https://www.youtube.com/playlist?list=PLKRu7cmBQlajbm2KGsICWbJOnusJfYvM

Bringing all the omics together

Multiomics is revolutionizing research, here’s why


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Learn why research leaders decided to use Multiomics in their work.
Subscribe to the Illumina video channel http://www.youtube.com/subscription_center?add_user=IlluminaInc\r
\r
A global genomics leader, Illumina provides comprehensive nextgeneration sequencing solutions to the research, clinical, and applied markets. Illumina technology is responsible for generating more than 90% of the world’s sequencing data. Through collaborative innovation, Illumina is fueling groundbreaking advancements in oncology, reproductive health, genetic disease, microbiology, agriculture, forensic science, and beyond.\r
\r
Data calculations on file. Illumina, Inc., 2015.\r
\r
View customer spotlight videos\r
https://www.youtube.com/playlist?list=PLKRu7cmBQlajfheLzgbI4S7xBn7IDbt79\r
\r
View Illumina webinars\r
https://www.youtube.com/playlist?list=PLKRu7cmBQlahpXlnrrXlQw9itVJ8yHwUZ\r
\r
View Illumina product videos\r
https://www.youtube.com/playlist?list=PLKRu7cmBQlaj6YuZmkfxZcT9twqDgP2Xd\r
\r
View Illumina support videos\r
https://www.youtube.com/playlist?list=PLKRu7cmBQlajbm2KGsICWbJOnusJfYvM

Multiomics is revolutionizing research, here’s why

Omics in Plant Sciences | Applications and their Sources


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drghulammuhudin Omics

Omics in Plant Sciences | Applications and their Sources

Sự Thật Về Cơ Thể Giúp Bạn Yêu Môn Sinh Học


Bạn đã bao giờ tự hỏi bạn chớp mắt bao nhiêu lần một phút? Hay bộ não sẽ lớn như thế nào nếu bạn duổi hết nếp nhăn đó ra? Hoặc nếu kéo căng tất cả các tĩnh mạch của mình trên một đường thì đường đó dài bao nhiêu? Cơ thể của chúng ta là những cơ chế hoạt động tốt, nên việc tìm hiểu điều gì khiến các hệ thống đó hoạt động hiệu quả luôn rất thú vị.
Ví dụ, bạn có biết rằng không phải tất cả chúng ta đều trải qua cảm giác nổi da gà? Một số nhà khoa học đã gợi ý rằng nổi da gà là do sự tiến hóa từ tổ tiên của chúng ta, những người đã giữ ấm cho bản thân thông qua nhiệt độ giữ được bên dưới lớp lông. Cơ thể bạn tích hợp nhiều thứ: đó là một tập hợp hóa học đi được, một dạng sống bền vững, một hiện tượng sinh học phức tạp. Vì vậy, sẽ luôn có điều gì đó để tìm hiểu về cơ thể, luôn có điều gì đó để tìm hiểu về những điều kỳ diệu của nó.

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